High Expression of CDCA7 in the Prognosis of Glioma and Its Relationship with Ferroptosis and Immunity

CDCA7 is a copy number amplification gene that promotes tumorigenesis. However, the clinical relevance and potential mechanisms of in glioma are unclear. expression level data were obtained from Chinese Glioma Genome Atlas (CGGA) The Cancer (TCGA) databases, enriched genes related signaling pathways explored. Data on CDCA7-related nine marker ferroptosis retrieved protein–protein interaction (PPI) network analysis was performed. correlation to tumor infiltration 22 kinds human immune cells association between checkpoint molecules analyzed. significantly increased gliomas comparison healthy tissues. Gene Ontology (GO) set enrichment (GSEA) revealed impact multiple biological processes pathways. may affect by interacting with cell cycle pathway P53 pathway. increase positively correlated suppressor involved tumor-infiltrating glioma. can be new prognostic factor for glioma, which closely ferroptosis, infiltration, checkpoint.